Importance of Compliance

What is compliance?*

"Compliance" is defined as taking medicine at the times and in the strength that the doctor prescribed. Common sense tells us that it is important. There are many factors that can cause compliance to fail, such as the lack of physical symptoms, difficulty swallowing pills, and forgetfulness.

*The effect of BINOSTO on compliance and adherence has not been studied.

Compliance and fractures

Compliance can mean the difference between fracturing and not fracturing. Many studies have been conducted by analyzing insurance claims to correlate the rate of fractures with medication refills (to tell if patients stayed on therapy). One large study showed that when women took their medicine as prescribed at least 80% of the time, the fracture rate was reduced significantly.1 Another study showed that staying compliant with medication and continuing to get refills on a consistent basis lowered the relative risk of fractures by 20% to 45%.2 This means that roughly 390,000 fractures were prevented per year in the US alone.

The effectiveness of osteoporosis treatment is monitored by bone scans and biochemical markers of bone turnover. When doctors see that a patient is not improving as they should over a period of time, compliance needs to be assessed.

Talk to your doctor

If you are having side effects that make taking your medicine difficult, or if you are taking medicine for several conditions and find it hard to remember when to take what, talk to your doctor. Be sure to get instructions you understand when a medicine has directions that are hard to follow. And if you no longer want to take a certain medicine, don’t just stop taking it—talk to your doctor first. Together, you can determine the best path forward.

  • 1. Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, Silverman S. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc. 2006 Aug;81(8):1013-22.
  • 2. Caro JJ, Ishak KJ, Huybrechts KF, Raggio G, Naujoks C. The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int. 2004 Dec;15(12):1003-8.

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